SYMPTOMS

In the early stages, increasing weakness in one limb, especially in a hand
Difficulty in walking; clumsiness with the hands; impaired speech
As the disease progresses, weakening of other limbs, perhaps accompanied by twitching, muscle cramping, and exaggerated, fater reflexes
Problems with chewing, swallowing, and breathing; drooling may occur
Rippling of the muscle fibers, called fasciculations, under the skin
Eventual paralysis